Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6116412 | 0.86 | NPC1 (0.61) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL8299970 | 0.84 | KMT2A (0.62) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL17221629 | 0.84 | KMT2A (0.62) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL8481152 | 0.84 | POLB (0.67) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL14600348 | 0.84 | KMT2A (0.58) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL6116459 | 0.82 | KMT2A (0.60) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL6116487 | 0.81 | ALDH1A1 (0.65) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL17221288 | 0.80 | KMT2A (0.57) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL6116347 | 0.80 | KMT2A (0.54) | KMT2AMAPTPOLBHTTL3MBTL1 | |
| SCHEMBL6116388 | 0.79 | KMT2A (0.62) | KMT2AMAPTPOLBHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474533-B1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | UNIV CENTRAL SOUTH (CN) | 2015-02-25 | — | — | EP | claimed |
| US-8377932-B2 | Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications | CENTRAL SOUTH UNIVERSITY (CN) | 2013-02-19 | — | — | US | claimed |
| EP-2474533-A1 | 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H) PYRIDONE COMPOUNDS AND THEIR SALTS, THEIR PREPARATION METHODS AND USE THEREOF | Central South University (CN) | 2012-07-11 | — | — | EP | claimed |
| US-20120129859-A1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | CENTRAL SOUTH UNIVERSITY (CN) | 2012-05-24 | — | — | US | claimed |
| CN-107652228-A | Anti- kidney fibrosis medicine 1（Substituted benzyl）The synthetic method of 5 trifluoromethyl 2 (1H) pyridonium salt hydrochlorates | 广州南新制药有限公司 | 2018-02-02 | — | — | CN | disclosed |
| EP-2474533-B1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | UNIV CENTRAL SOUTH (CN) | 2015-02-25 | — | — | EP | disclosed |
| EP-2474533-B1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | UNIV CENTRAL SOUTH (CN) | 2015-02-25 | — | — | EP | disclosed |
| US-8377932-B2 | Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications | CENTRAL SOUTH UNIVERSITY (CN) | 2013-02-19 | — | — | US | disclosed |
| US-8377932-B2 | Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications | CENTRAL SOUTH UNIVERSITY (CN) | 2013-02-19 | — | — | US | disclosed |
| EP-2474533-A1 | 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2-(1H) PYRIDONE COMPOUNDS AND THEIR SALTS, THEIR PREPARATION METHODS AND USE THEREOF | Central South University (CN) | 2012-07-11 | — | — | EP | disclosed |
| US-20120129859-A1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | CENTRAL SOUTH UNIVERSITY (CN) | 2012-05-24 | — | — | US | disclosed |
| US-20120129859-A1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | CENTRAL SOUTH UNIVERSITY (CN) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129859-A1 | PREPARATION OF 1-(SUBSTITUTED BENZYL)-5-TRIFLUOROMETHYL-2(1H)PYRIDONE COMPOUNDS AND SALTS THEREOF AND THEIR APPLICATIONS | CFTR, PNPO, COL1A1 | KMT2A 4135/4885MAPT 4609/4885POLB 2086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.