SCHEMBL14600446

SCHEMBL14600446

CCCCOc1ccc2c(c1)C(C)(C)c1cc(-c3c4ccccc4c(-c4c5ccccc5c(-c5ccc6c(c5)C(C)(C)c5cc(-c7c8ccccc8c(-c8ccccc8)c8ccccc78)ccc5-6)c5ccccc45)c4ccccc34)ccc1-2

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 4/20 0.46
ALK Q9UM73 5/20 0.42
PTPN1 P18031 1/20 0.41
DHODH Q02127 1/20 0.41
PTPN11 Q06124 5/20 0.41
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP19A1 P11511 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
PLA2G2A P14555 1/20 0.39
LTA4H P09960 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14600391 0.99 PDK2 (0.47) PDK2ALKPTPN1DHODHPTPN11
SCHEMBL14600359 0.96 PDK2 (0.46) PDK2ALKPTPN1DHODHPTPN11
SCHEMBL14600383 0.94 CYP2D6 (0.41) PDK2PTPN1DHODHCYP1A2CYP2D6
SCHEMBL14600337 0.94 CYP2D6 (0.43) PDK2PTPN1DHODHCYP1A2CYP2D6
SCHEMBL14600331 0.93 CYP2D6 (0.42) PDK2PTPN1DHODHCYP1A2CYP2D6
SCHEMBL14600421 0.93 CYP2D6 (0.44) PDK2ALKCYP1A2CYP2D6CYP19A1
SCHEMBL14600489 0.92 CYP2D6 (0.43) PDK2ALKCYP1A2CYP2D6CYP19A1
SCHEMBL14600345 0.91 CYP2D6 (0.45) PDK2ALKCYP1A2CYP2D6CYP19A1
SCHEMBL14600410 0.90 CYP2D6 (0.44) PDK2ALKCYP1A2CYP2D6CYP19A1
SCHEMBL10154004 0.89 PDK2 (0.46) PDK2ALKCYP1A2CYP2D6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166240-B2 Hydrocarbon compounds, materials for organic electroluminescent elements and organic electroluminescent elements MITSUI CHEMICALS, INC. (JP) 2007-01-23 US disclosed