Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600767 | 0.82 | GSK3B (0.36) | GAARIPK1DCLK1DYRK3ROCK2 | |
| SCHEMBL5034026 | 0.80 | MAPK7 (0.42) | GAARIPK1DCLK1DYRK3ROCK2 | |
| SCHEMBL14600761 | 0.79 | HPGD (0.42) | MAP3K5LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL10067976 | 0.77 | GSK3B (0.44) | GAAGSK3BPOLBALDH1A1KMT2A | |
| SCHEMBL5037204 | 0.70 | NOTUM (0.36) | DCLK1DYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL14286143 | 0.67 | MAPK1 (0.46) | DCLK1DYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL28063183 | 0.64 | POLB (0.59) | EGFRPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL23859765 | 0.63 | FABP1 (0.48) | LMNAPOLBATRALDH1A1KMT2A | |
| SCHEMBL30075079 | 0.63 | FABP1 (0.48) | LMNAPOLBATRALDH1A1KMT2A | |
| SCHEMBL14286148 | 0.63 | MAPK1 (0.42) | LMNAPOLBALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169800-B2 | Imidazole compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |