Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.37 |
| ▸ | ATP4B | P51164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037077 | 0.90 | ALDH1A1 (0.36) | MAPK1MAPK10HPGDALDH1A1HTT | |
| SCHEMBL5037204 | 0.85 | NOTUM (0.36) | — | |
| SCHEMBL14286134 | 0.82 | MAPK1 (0.46) | MAPK1MAPK10HPGDALDH1A1HTT | |
| SCHEMBL14600761 | 0.80 | HPGD (0.42) | MAPK1HPGDALDH1A1LMNAMEN1 | |
| SCHEMBL5034026 | 0.79 | MAPK7 (0.42) | MAPK1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14286139 | 0.79 | ROCK2 (0.40) | MAPK1MAPK10MEN1KMT2A | |
| SCHEMBL5784221 | 0.76 | HCAR1 (0.39) | ALDH1A1 | |
| SCHEMBL14278772 | 0.75 | MAPK1 (0.49) | MAPK1MAPK10HPGDALDH1A1HTT | |
| SCHEMBL5038382 | 0.73 | MAPK1 (0.49) | MAPK1MAPK10HPGDALDH1A1HTT | |
| SCHEMBL14286171 | 0.73 | MAPK1 (0.52) | MAPK1MAPK10HPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |