Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970338 | 0.89 | NAMPT (0.38) | NAMPTDRD2DRD3CYP2D6ITGB2 | |
| SCHEMBL3970340 | 0.89 | NAMPT (0.38) | NAMPTDRD2DRD3CYP2D6ITGB2 | |
| SCHEMBL14091686 | 0.89 | NAMPT (0.38) | NAMPTDRD2DRD3CYP2D6ITGB2 | |
| SCHEMBL3963559 | 0.88 | STS (0.42) | NAMPTNPC1EPHX2RAB9A | |
| SCHEMBL3963560 | 0.88 | STS (0.42) | NAMPTNPC1EPHX2RAB9A | |
| SCHEMBL14091685 | 0.88 | STS (0.42) | NAMPTNPC1EPHX2RAB9A | |
| SCHEMBL13768681 | 0.83 | NAMPT (0.38) | NAMPTDRD2DRD3MTNR1AMTNR1B | |
| SCHEMBL3961017 | 0.83 | NAMPT (0.38) | NAMPTDRD2DRD3MTNR1AMTNR1B | |
| SCHEMBL3961020 | 0.83 | NAMPT (0.38) | NAMPTDRD2DRD3MTNR1AMTNR1B | |
| SCHEMBL14601593 | 0.81 | NAMPT (0.46) | NAMPTDRD2DRD3ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028131-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |