Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.68 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.68 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.68 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.68 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.68 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.68 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.35 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601901 | 0.87 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4427116 | 0.87 | PSEN1 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18814505 | 0.86 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18814902 | 0.86 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4422942 | 0.84 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4436231 | 0.84 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18814903 | 0.82 | PSEN1 (0.67) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14601886 | 0.81 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8288868 | 0.81 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14601876 | 0.81 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10865188-B2 | Dibenzo azepine compounds and their use in the treatment of otic diseases and disorders | Pipeline Therapeutics, Inc. (US) | 2020-12-15 | — | — | US | disclosed |
| EP-3368515-B1 | DIBENZO AZEPINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OTIC DISEASES AND DISORDERS | INCEPTION 3 INC (US) | 2019-07-17 | — | — | EP | disclosed |
| US-20190194140-A1 | DIBENZO AZEPINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OTIC DISEASES AND DISORDERS | CONTINEUM THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| US-10301266-B2 | Dibenzo azepine compounds and their use in the treatment of otic diseases and disorders | INCEPTION 3, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| WO-2017075264-A1 | DIBENZO AZEPINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OTIC DISEASES AND DISORDERS | INCEPTION 3, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194140-A1 | DIBENZO AZEPINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OTIC DISEASES AND DISORDERS | OTC, NISCH, SLC26A4 | PSEN1 418/4885PSEN2 291/4885APH1B 675/4885 |
| US-10301266-B2 | Dibenzo azepine compounds and their use in the treatment of otic diseases and disorders | OTC, NISCH, SLC26A4 | PSEN1 418/4885PSEN2 291/4885APH1B 675/4885 |
| US-10865188-B2 | Dibenzo azepine compounds and their use in the treatment of otic diseases and disorders | OTC, NISCH, SLC26A4 | PSEN1 418/4885PSEN2 291/4885APH1B 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.