SLC26A4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3976556	0.69	7/20
SCHEMBL4124805	0.67	7/20
SCHEMBL15897959	0.65	7/20
SCHEMBL15019934	0.64	7/20
SCHEMBL1839725	0.62	7/20
SCHEMBL20695245	0.59	7/20
SCHEMBL19820374	0.57	7/20
SCHEMBL16655989	0.55	7/20
SCHEMBL15020090	0.51	7/20
SCHEMBL2772042	0.44	7/20
SCHEMBL6976339	0.54	6/20
SCHEMBL5746156	0.52	6/20
SCHEMBL12716192	0.51	6/20
SCHEMBL3768002	0.44	6/20
SCHEMBL11262518	0.52	5/20
SCHEMBL12470257	0.44	5/20
SCHEMBL15211549	0.61	4/20
SCHEMBL15201819	0.51	4/20
SCHEMBL720265	0.50	4/20
SCHEMBL9432912	0.48	4/20

Clinical trials — most relevant to SLC26A4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Genetic Basis for Variation in the Renal Elimination of Metformin	PHASE4	COMPLETED
Effect of Age on the Renal Clearance of Adefovir	PHASE4	WITHDRAWN
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)	PHASE4	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
BSEP Function Rescue During Childhood Inhereditary Cholestatic Diseases	PHASE2/PHASE3	WITHDRAWN
CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops	PHASE2	UNKNOWN
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Clinical Phenotypic Characteristics of SC26A4	nan	UNKNOWN
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes	nan	RECRUITING
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN
Genotype-phenotype Correlation of SLC26A4 in CI Patients With EVA	nan	UNKNOWN
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
SLC13A5 Deficiency Natural History Study - Remote Only	nan	ENROLLING_BY_INVITATION
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Prevalence and Risk Factors of Nephrocalcinosis in Children at Sohag University Hospital	nan	UNKNOWN
Oxalate and Citrate	nan	RECRUITING
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals	nan	ENROLLING_BY_INVITATION
Bronchial Trans-epithelial Transport in Patients With Idiopathic Multiple Dilations of the Bronchi	nan	COMPLETED
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Neurologic Injuries in Adults With Urea Cycle Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC26A4 binder may also engage these)

Protein	Name	Similarity
Q9R154	—	1.000	Q9R154 →
Q9R155	—	0.996	Q9R155 →
Q924C9	—	0.971	Q924C9 →
A0FKN5	—	0.971	A0FKN5 →
Q9WVC8	—	0.967	Q9WVC8 →
SLC26A3	Chloride anion exchanger	0.956	landscape →
Q9SXS2	—	0.953	Q9SXS2 →
Q9SV13	—	0.952	Q9SV13 →
A2VDL4	—	0.948	A2VDL4 →
O35874	—	0.946	O35874 →
Q65AC2	—	0.944	Q65AC2 →
P43007	—	0.944	P43007 →
Q8CIW6	—	0.940	Q8CIW6 →
Q9LW86	—	0.940	Q9LW86 →
SLC26A6	Solute carrier family 26 member 6	0.938	landscape →
P50443	—	0.938	P50443 →
Q7T2C4	—	0.938	Q7T2C4 →
Q5R6B8	—	0.938	Q5R6B8 →
O04289	—	0.936	O04289 →
SLC9B2	Sodium/hydrogen exchanger 9B2	0.935	landscape →
Q9BEG8	—	0.935	Q9BEG8 →
Q8K415	—	0.934	Q8K415 →
Q69DJ1	—	0.933	Q69DJ1 →
Q5U4D8	—	0.932	Q5U4D8 →
Q8BHK3	—	0.932	Q8BHK3 →
Q62273	—	0.932	Q62273 →
Q9XT77	—	0.932	Q9XT77 →
Q91WC3	—	0.931	Q91WC3 →
Q9GJY3	—	0.931	Q9GJY3 →
Q495M3	—	0.930	Q495M3 →