Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.77 |
| ▸ | MMP10 | P09238 | 2/20 | 0.64 |
| ▸ | MMP8 | P22894 | 2/20 | 0.64 |
| ▸ | MMP9 | P14780 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360162 | 0.93 | MMP13 (0.88) | MMP13MMP10MMP8MMP9CYP1A2 | |
| SCHEMBL14602299 | 0.91 | MMP13 (0.72) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL14602302 | 0.91 | MMP13 (0.75) | MMP13MMP10MMP8MMP9CYP1A2 | |
| SCHEMBL14602303 | 0.89 | MMP13 (0.69) | MMP13MMP10MMP8MMP9CYP1A2 | |
| SCHEMBL29838134 | 0.88 | MMP13 (1.00) | MMP13MMP10MMP8MMP9SMN1; SMN2 | |
| SCHEMBL8358823 | 0.88 | MMP13 (1.00) | MMP13MMP10MMP8MMP9SMN1; SMN2 | |
| SCHEMBL14602298 | 0.86 | MMP13 (0.71) | MMP13MMP10MMP8MMP9CYP1A2 | |
| SCHEMBL4716566 | 0.85 | MMP13 (0.90) | MMP13MMP10MMP8MMP9HCRTR1 | |
| SCHEMBL8357428 | 0.85 | MMP13 (0.90) | MMP13MMP10MMP8MMP9ALDH1A1 | |
| SCHEMBL5615610 | 0.85 | MMP13 (0.77) | MMP13MMP10MMP8MMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |