Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fexofenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.73 |
| ▸ | DRD3 | P35462 | 5/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | BLM | P54132 | 3/20 | 0.73 |
| ▸ | HTR2A | P28223 | 3/20 | 0.73 |
| ▸ | HTR2B | P41595 | 3/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.73 |
| ▸ | APEX1 | P27695 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.73 |
| ▸ | DRD2 | P14416 | 3/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fexofenadine SCHEMBL6382537 | 0.86 | HRH1 (0.96) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL6382541 | 0.86 | HRH1 (0.96) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL3178320 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL4901 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL1972366 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL1561082 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL7104316 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL4900 | 0.85 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL20531399 | 0.84 | HRH1 (0.98) | DRD3KCNH2LMNAHRH1BLM | |
| Fexofenadine SCHEMBL40915 | 0.84 | HRH1 (1.00) | DRD3KCNH2LMNAHRH1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013009271-A1 | NEW IMPROVED DRY POWDER FORMULATION | BILGIC MAHMUT (TR) | 2013-01-17 | — | — | WO | claimed |
| WO-2013009271-A1 | NEW IMPROVED DRY POWDER FORMULATION | BILGIC MAHMUT (TR) | 2013-01-17 | — | — | WO | disclosed |