Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.54 |
| ▸ | TYK2 | P29597 | 15/20 | 0.54 |
| ▸ | JAK3 | P52333 | 15/20 | 0.54 |
| ▸ | JAK2 | O60674 | 12/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14603945 | 0.92 | JAK1 (0.54) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL2277271 | 0.89 | JAK1 (0.60) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL14603696 | 0.87 | JAK1 (0.41) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL2281915 | 0.86 | JAK1 (0.57) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL25280432 | 0.85 | JAK1 (0.49) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL2226559 | 0.85 | JAK1 (0.46) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL30480407 | 0.85 | JAK1 (0.49) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL25280431 | 0.85 | JAK1 (0.49) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL2272132 | 0.84 | JAK1 (0.46) | JAK1TYK2JAK3JAK2CYP3A4 | |
| SCHEMBL2282946 | 0.84 | JAK1 (0.54) | JAK1TYK2JAK3JAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013007765-A1 | FUSED TRICYCLIC COMPOUNDS FOR USE AS INHIBITORS OF JANUS KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |