Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | ITK | Q08881 | 1/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.70 |
| ▸ | CDK2 | P24941 | 10/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.46 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605971 | 0.91 | LCK (0.62) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14605899 | 0.87 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605947 | 0.87 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605953 | 0.84 | LCK (0.95) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14606053 | 0.80 | LCK (0.65) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14605898 | 0.80 | LCK (0.62) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14605962 | 0.79 | LCK (0.78) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14606097 | 0.78 | LCK (0.48) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606070 | 0.78 | LCK (0.59) | LCKITKAURKBCDK2CCNA2 | |
| SCHEMBL14605963 | 0.78 | LCK (0.59) | LCKITKAURKBCDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |