Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 3/20 | 0.38 |
| ▸ | GRK6 | P43250 | 8/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605904 | 0.86 | LCK (0.59) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606105 | 0.86 | LCK (0.46) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606069 | 0.84 | AURKB (0.46) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605945 | 0.83 | LCK (0.45) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606042 | 0.82 | LCK (0.47) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605960 | 0.80 | LCK (0.50) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14606097 | 0.78 | LCK (0.48) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605899 | 0.78 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605947 | 0.78 | AURKB (0.54) | LCKITKAURKBPLK4PAK4 | |
| SCHEMBL14605951 | 0.77 | LCK (0.75) | LCKITKAURKBPLK4PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |