Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 10/20 | 0.47 |
| ▸ | APP | P05067 | 9/20 | 0.47 |
| ▸ | BCHE | P06276 | 8/20 | 0.47 |
| ▸ | AQP1 | P29972 | 2/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13795703 | 1.00 | MRGPRX1 (0.51) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13796330 | 0.93 | MRGPRX1 (0.58) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13795833 | 0.92 | NPY5R (0.52) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13795622 | 0.90 | NPY5R (0.64) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13795878 | 0.90 | MRGPRX1 (0.53) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL14606846 | 0.90 | MRGPRX1 (0.53) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13796342 | 0.89 | NPY5R (0.57) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13795588 | 0.89 | NPY5R (0.48) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13796090 | 0.88 | NPY5R (0.51) | MRGPRX1NPY5RSLC6A4ACHEAPP | |
| SCHEMBL13796077 | 0.88 | NPY5R (0.50) | MRGPRX1NPY5RSLC6A4ACHEAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037836-A1 | Melanin concentrating hormone; obesity and related disorders, anxiety, or depression; trans-4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-2-trifluoromethoxy-benzenesulfonamide | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037836-A1 | Melanin concentrating hormone; obesity and related disorders, anxiety, or depression; trans-4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-2-trifluoromethoxy-benzenesulfonamide | MCHR1, MCHR2, MC4R | MRGPRX1 113/4885NPY5R 11/4885SLC6A4 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.