Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14009231 | 0.93 | MAPT (0.52) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14609607 | 0.82 | NPC1 (0.49) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14609403 | 0.81 | NPC1 (0.67) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14609402 | 0.80 | CYP11B1 (0.43) | MAPTSMN1; SMN2LMNAKDM4EF10 | |
| SCHEMBL14609438 | 0.80 | LMNA (0.44) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL14009158 | 0.78 | NPC1 (0.54) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14609436 | 0.78 | CA1 (0.38) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14009166 | 0.78 | HRH3 (0.49) | MAPTNPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL14009284 | 0.78 | CA1 (0.50) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14009173 | 0.77 | KLKB1 (0.57) | MAPTNPC1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022258-A1 | NOVEL HIGH AFFINITY THIOPHENE-BASED AND FURAN-BASED KINASE LIGANDS | SCHERING CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |