Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14009299 | 0.91 | ROCK1 (0.52) | ROCK1MEN1POLBHPGDKMT2A | |
| SCHEMBL14009275 | 0.82 | MEN1 (0.50) | ROCK1MEN1KMT2AGAARAB9A | |
| SCHEMBL14009250 | 0.78 | MAPT (0.53) | ROCK1MEN1POLBKMT2ARAB9A | |
| SCHEMBL14009058 | 0.78 | ROCK1 (0.51) | ROCK1MEN1POLBHPGDKMT2A | |
| SCHEMBL14009228 | 0.77 | TYK2 (0.46) | ROCK1MEN1POLBHPGDKMT2A | |
| SCHEMBL14531257 | 0.74 | RAB9A (0.54) | ROCK1MEN1HPGDKMT2ARAB9A | |
| SCHEMBL14009037 | 0.72 | ROCK1 (0.52) | ROCK1MEN1KMT2ARAB9ARXFP1 | |
| SCHEMBL14009076 | 0.71 | HTT (0.53) | ROCK1MEN1KMT2AGAARAB9A | |
| SCHEMBL1165268 | 0.70 | SMN1; SMN2 (0.53) | ROCK1POLBCYP1A2CYP2C9RAB9A | |
| SCHEMBL14008995 | 0.69 | KDM4E (0.53) | ROCK1MEN1POLBHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022258-A1 | NOVEL HIGH AFFINITY THIOPHENE-BASED AND FURAN-BASED KINASE LIGANDS | SCHERING CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |