Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460994 | 0.89 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3R1PIK3CB | |
| SCHEMBL734709 | 0.83 | PIK3CD (0.39) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3R2 | |
| SCHEMBL733448 | 0.80 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3R1PIK3CB | |
| SCHEMBL735025 | 0.76 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3R2 | |
| SCHEMBL3956752 | 0.73 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3R1PIK3CB | |
| SCHEMBL734710 | 0.73 | PIK3CG (0.57) | PIK3CGPIK3CDPIK3CBPIK3R2 | |
| SCHEMBL734503 | 0.72 | PIK3CG (0.49) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3R2 | |
| SCHEMBL735272 | 0.71 | PIK3CD (0.45) | PIK3CGPIK3CDPIK3R1PIK3CB | |
| SCHEMBL733966 | 0.70 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3R1PIK3CB | |
| SCHEMBL732766 | 0.68 | PIK3CD (0.52) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4642309-B2 | — | — | 2011-03-02 | — | — | JP | claimed |
| JP-2003531209-A | — | — | 2003-10-21 | — | — | JP | claimed |
| EP-1278748-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001081346-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2001-11-01 | — | — | WO | claimed |