Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 4/20 | 0.46 |
| ▸ | SOD1 | P00441 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL267773 | 1.00 | POLA1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL6009627 | 1.00 | POLA1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL267397 | 1.00 | POLA1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL267401 | 0.90 | PTGS1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL12450207 | 0.90 | PTGS1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL12887758 | 0.90 | PTGS1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL6008134 | 0.90 | PTGS1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL267488 | 0.90 | PTGS1 (0.46) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL280154 | 0.84 | SOD1 (0.47) | POLA1SOD1CYP3A4MAPTMEN1 | |
| SCHEMBL280188 | 0.84 | SOD1 (0.47) | POLA1SOD1CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015757-A2 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |