Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836012 | 0.81 | OPRM1 (0.55) | OPRM1HDAC1TACR1HTR2AAKR1C1 | |
| SCHEMBL4261726 | 0.81 | OPRM1 (0.62) | OPRM1HDAC1TACR1AKR1C1ROCK2 | |
| Hydrochloric Acid SCHEMBL1308247 | 0.80 | OPRM1 (0.61) | OPRM1HDAC1TACR1AKR1C1OPRD1 | |
| Hydrochloric Acid SCHEMBL27854093 | 0.80 | OPRM1 (0.54) | OPRM1HDAC1TACR1HTR2AAKR1C1 | |
| Hydrochloric Acid SCHEMBL6082811 | 0.79 | OPRM1 (0.59) | OPRM1HDAC1TACR1AKR1C1ROCK2 | |
| SCHEMBL4325002 | 0.74 | OPRM1 (0.66) | OPRM1HDAC1TACR1AKR1C1OPRD1 | |
| Hydrochloric Acid SCHEMBL1309302 | 0.73 | OPRM1 (0.64) | OPRM1HDAC1TACR1AKR1C1OPRD1 | |
| SCHEMBL6866343 | 0.72 | OPRM1 (0.79) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL38041 | 0.71 | OPRM1 (0.62) | OPRM1HDAC1TACR1HTR2AAKR1C1 | |
| Normeperidine SCHEMBL341796 | 0.71 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007016643-A2 | A METHOD FOR EXTENDING LONGEVITY USING NPC1L1 ANTAGONISTS | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2007-02-08 | — | — | WO | disclosed |