Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 8/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522005 | 0.80 | PTGS1 (0.48) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL267186 | 0.80 | PTGS1 (0.41) | PTGS1NR1H3NR1H2PTPN1FNTA | |
| SCHEMBL12450198 | 0.77 | PTGS1 (0.66) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL267183 | 0.77 | PTGS1 (0.66) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL261043 | 0.77 | PTGS1 (0.66) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL280378 | 0.73 | NR1H3 (0.35) | PTGS1NR1H3NR1H2 | |
| SCHEMBL12522085 | 0.71 | PTGS1 (0.44) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL12522448 | 0.71 | PTGS1 (0.37) | PTGS1NR1H3 | |
| SCHEMBL12522439 | 0.70 | NR1H3 (0.35) | PTGS1NR1H3NR1H2PTPN1 | |
| SCHEMBL12704709 | 0.69 | SOD1 (0.47) | PTGS1NR1H3NR1H2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015757-A2 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |