Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746121 | 0.89 | DRD4 (0.43) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4751521 | 0.88 | DRD2 (0.57) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4751391 | 0.87 | DRD4 (0.42) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4947711 | 0.86 | DRD2 (0.49) | DRD2GRM2DRD4DRD3CCR3 | |
| SCHEMBL4949652 | 0.86 | DRD2 (0.49) | DRD2GRM2DRD4DRD3CCR3 | |
| SCHEMBL4947698 | 0.86 | DRD2 (0.49) | DRD2GRM2DRD4DRD3CCR3 | |
| SCHEMBL4949174 | 0.86 | DRD2 (0.54) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4947064 | 0.86 | GRM2 (0.42) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4753926 | 0.84 | DRD2 (0.46) | DRD2GRM2DRD4DRD3MCHR1 | |
| SCHEMBL4947913 | 0.84 | DRD2 (0.40) | DRD2GRM2DRD4DRD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |