Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.39 |
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947913 | 0.93 | DRD2 (0.40) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4945981 | 0.91 | DRD2 (0.39) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4942307 | 0.90 | DRD2 (0.49) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4950373 | 0.90 | GRM2 (0.39) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4949652 | 0.90 | DRD2 (0.49) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4947698 | 0.90 | DRD2 (0.49) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4947711 | 0.90 | DRD2 (0.49) | HTR2AHTR2CGRM2DRD2DRD4 | |
| SCHEMBL4948371 | 0.89 | GRM2 (0.52) | GRM2DRD2DRD4DRD3 | |
| SCHEMBL4948882 | 0.89 | DRD2 (0.42) | GRM2DRD2DRD4DRD3KDM4E | |
| SCHEMBL4949787 | 0.88 | DRD2 (0.37) | HTR2AHTR2CGRM2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |