Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14578712 | 0.97 | HSD17B10 (0.39) | HSD17B10SMN1; SMN2HPGDBTKCHRM2 | |
| SCHEMBL629002 | 0.81 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL629003 | 0.81 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL13541087 | 0.76 | HSD17B10 (0.35) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL13541170 | 0.76 | HSD17B10 (0.35) | HSD17B10SMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL29148977 | 0.75 | HSD17B10 (0.41) | HSD17B10SMN1; SMN2HPGDBTKCHRM2 | |
| SCHEMBL6360431 | 0.74 | HSD17B10 (0.40) | HSD17B10SMN1; SMN2HPGDBTKCHRM2 | |
| SCHEMBL2450264 | 0.72 | CHRM2 (0.37) | HSD17B10SMN1; SMN2HPGDCHRM2CHRM1 | |
| SCHEMBL29149056 | 0.72 | HSD17B10 (0.41) | HSD17B10SMN1; SMN2HPGDBTKCHRM2 | |
| SCHEMBL35211488 | 0.71 | HSD17B10 (0.40) | HSD17B10SMN1; SMN2HPGDBTKCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179918-B2 | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-20 | — | — | US | disclosed |