Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | CFTR | P13569 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132112 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL6132103 | 0.83 | PIK3CA (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL6132108 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL12904313 | 0.79 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL27166203 | 0.78 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPOLB | |
| SCHEMBL30002937 | 0.76 | PIK3CA (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL6132106 | 0.76 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL909694 | 0.76 | PIK3CA (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR | |
| SCHEMBL27166213 | 0.73 | BCHE (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGCYP1A2 | |
| SCHEMBL910015 | 0.72 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4646626-B2 | — | — | 2011-03-09 | — | — | JP | claimed |
| JP-2006500361-A | — | — | 2006-01-05 | — | — | JP | claimed |
| EP-1537102-A1 | INHIBITION OF PHSPHOINOSTIDE 3-DINASE BETA | Kinacia Pty Ltd. (AU) | 2005-06-08 | — | — | EP | claimed |
| WO-2004016607-A1 | INHIBITION OF PHOSPHOINOSITIDE 3-KINASE BETA | KINACIA PTY LTD. (AU) | 2004-02-26 | — | — | WO | claimed |
| EP-1537102-A1 | INHIBITION OF PHSPHOINOSTIDE 3-DINASE BETA | Kinacia Pty Ltd. (AU) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004016607-A1 | INHIBITION OF PHOSPHOINOSITIDE 3-KINASE BETA | KINACIA PTY LTD. (AU) | 2004-02-26 | — | — | WO | disclosed |