Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289096 | 0.89 | GSK3B (0.55) | GSK3BNPC1CHEK1CDK2CYP3A4 | |
| SCHEMBL14545841 | 0.89 | GSK3B (0.56) | GSK3BCHEK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13289101 | 0.89 | GSK3B (0.56) | GSK3BCHEK1CDK2NAMPT | |
| SCHEMBL12954475 | 0.89 | GSK3B (0.58) | GSK3BCHEK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13289097 | 0.88 | GSK3B (0.59) | GSK3BCHEK1CDK2NAMPTLMNA | |
| SCHEMBL14607249 | 0.87 | GSK3B (0.55) | GSK3BCHEK1CDK2CYP3A4CYP2D6 | |
| SCHEMBL12953928 | 0.87 | GSK3B (0.55) | GSK3BNPC1CHEK1CDK2NAMPT | |
| SCHEMBL13289388 | 0.87 | GSK3B (0.56) | GSK3BCHEK1CDK2 | |
| SCHEMBL13289106 | 0.87 | GSK3B (0.53) | GSK3BCHEK1CDK2NAMPTALDH1A1 | |
| SCHEMBL13289362 | 0.87 | GSK3B (0.61) | GSK3BCHEK1CDK2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | SCHERING CORPORATION | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | CDK2, CDK5, CDKN1A | GSK3B 937/4885NPC1 3456/4885CHEK1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.