Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 0.67 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.52 |
| ▸ | PYGL | P06737 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | KYNU | Q16719 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614312 | 0.91 | ITGAL (0.56) | ITGALITGB2ICAM1PYGLCA2 | |
| SCHEMBL14614314 | 0.87 | ITGAL (0.52) | ITGALITGB2ICAM1PYGLCA2 | |
| SCHEMBL14614282 | 0.85 | ITGAL (0.55) | ITGALITGB2ICAM1PYGLCA2 | |
| SCHEMBL13666886 | 0.85 | ITGAL (0.65) | ITGALPYGLKYNUMRGPRX4ITGB1 | |
| SCHEMBL14614083 | 0.83 | ITGAL (0.48) | ITGALITGB2ICAM1PYGLCA2 | |
| SCHEMBL14614003 | 0.83 | ITGAL (0.51) | ITGALITGB2ICAM1PYGLCA2 | |
| SCHEMBL18362373 | 0.81 | ITGAL (0.55) | ITGALKYNUMEN1KMT2AOPRK1 | |
| SCHEMBL18885222 | 0.81 | ITGAL (0.66) | ITGALITGB2ICAM1KYNUMEN1 | |
| SCHEMBL10112626 | 0.81 | ITGAL (0.65) | ITGALITGB2ICAM1KYNUMEN1 | |
| SCHEMBL12063569 | 0.81 | ITGAL (1.00) | ITGALITGB2ICAM1ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1063982-B1 | ANTAGONISTS FOR TREATMENT OF CD11/CD18 ADHESION RECEPTOR MEDIATED DISORDERS | GENENTECH INC (US) | 2007-02-14 | — | — | EP | disclosed |