Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 3/20 | 0.55 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.55 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614312 | 0.86 | ITGAL (0.56) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL14613923 | 0.85 | ITGAL (0.67) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL14614311 | 0.83 | ITGAL (0.48) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL14614314 | 0.81 | ITGAL (0.52) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL14614020 | 0.81 | ITGAL (0.53) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL18362383 | 0.79 | ITGAL (0.76) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14613756 | 0.79 | ITGAL (0.53) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL23153595 | 0.78 | ITGAL (0.66) | ITGALITGB2ICAM1ITGB1ITGA5 | |
| SCHEMBL14614057 | 0.78 | ITGAL (0.54) | ITGALITGB2ICAM1MRGPRX4CA2 | |
| SCHEMBL14614083 | 0.78 | ITGAL (0.48) | ITGALITGB2ICAM1MRGPRX4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |