Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24372424 | 0.88 | TAAR1 (0.54) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL28098160 | 0.87 | TAAR1 (0.44) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL15591097 | 0.85 | BACE1 (0.46) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL24372740 | 0.83 | CNR1 (0.45) | TAAR1BACE1HTR1AHTR2ACNR1 | |
| SCHEMBL24372416 | 0.82 | BACE1 (0.49) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL10732579 | 0.81 | BACE1 (0.46) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL11791277 | 0.81 | TRPA1 (0.41) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL15626765 | 0.78 | TAAR1 (0.52) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL11800179 | 0.78 | SKP2 (0.44) | TAAR1BACE1HTR1AHTR1DHTR1B | |
| SCHEMBL14614986 | 0.78 | TAAR1 (0.48) | TAAR1HTR1DCYP1A2CYP2A6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757584-A1 | Heterocyclic substituted amides, their production and their use | Abbott GmbH & Co. KG (DE) | 2007-02-28 | — | — | EP | disclosed |