Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 4/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5566529 | 0.99 | KEAP1 (0.43) | KEAP1NFE2L2TNFRSF1AKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5566521 | 0.99 | KEAP1 (0.43) | KEAP1NFE2L2TNFRSF1AKMT2AMEN1 | |
| SCHEMBL5564347 | 0.88 | TNFRSF1A (0.46) | TNFRSF1AKMT2AMEN1LMNAGAA | |
| SCHEMBL5564349 | 0.88 | TNFRSF1A (0.46) | TNFRSF1AKMT2AMEN1LMNAGAA | |
| SCHEMBL14524489 | 0.88 | KEAP1 (0.43) | KEAP1NFE2L2KMT2AMEN1LMNA | |
| SCHEMBL5560086 | 0.87 | MEN1 (0.52) | TNFRSF1AKMT2AMEN1LMNAGAA | |
| SCHEMBL5564208 | 0.87 | MEN1 (0.52) | TNFRSF1AKMT2AMEN1LMNAGAA | |
| SCHEMBL5564206 | 0.87 | MEN1 (0.52) | TNFRSF1AKMT2AMEN1LMNAGAA | |
| SCHEMBL6040607 | 0.86 | KEAP1 (0.48) | KEAP1NFE2L2TNFRSF1AHPGD | |
| SCHEMBL6040600 | 0.86 | KEAP1 (0.48) | KEAP1NFE2L2TNFRSF1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173129-B2 | Sulfonamide-substituted chalcone derivatives and their use to treat diseases | ATHERO GENICS, INC. (US) | 2007-02-06 | — | — | US | disclosed |