Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 3/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578816 | 0.85 | HDAC1 (0.48) | HDAC1HDAC6NOTUMGAA | |
| SCHEMBL5578970 | 0.85 | HDAC1 (0.49) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578576 | 0.83 | HDAC1 (0.47) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578448 | 0.80 | NOTUM (0.48) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578839 | 0.78 | NOTUM (0.52) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5579351 | 0.77 | NOTUM (0.50) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578527 | 0.76 | NOTUM (0.50) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578568 | 0.75 | NOTUM (0.43) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL5578983 | 0.73 | HDAC1 (0.53) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 | |
| SCHEMBL14618521 | 0.73 | HDAC1 (0.38) | HDAC1HDAC6NOTUMSLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | disclosed |