Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.45 |
| ▸ | CDK1 | P06493 | 10/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522765 | 0.81 | CDK1 (0.50) | CDK2CDK1CCNB1CCNE1ADORA2A | |
| SCHEMBL12522769 | 0.77 | CDK1 (0.53) | CDK2CDK1CCNB1CCNE1ADORA2A | |
| SCHEMBL15499049 | 0.77 | CDK1 (0.47) | CDK2CDK1CCNB1CCNE1ADORA2A | |
| SCHEMBL14087936 | 0.77 | CDK1 (0.47) | CDK2CDK1CCNB1CCNE1CCNA2 | |
| SCHEMBL15887583 | 0.77 | CDK1 (0.47) | CDK2CDK1CCNB1CCNE1CCNA2 | |
| SCHEMBL16259446 | 0.74 | CDK1 (0.44) | CDK2CDK1CCNB1CCNE1CCNA2 | |
| SCHEMBL3209666 | 0.74 | CDK1 (0.60) | CDK2CDK1CCNB1CCNE1CCNA2 | |
| SCHEMBL20857246 | 0.74 | CDK1 (0.49) | CDK2CDK1CCNB1CCNE1ADORA2A | |
| SCHEMBL21562148 | 0.74 | CDK1 (0.49) | CDK2CDK1CCNB1CCNE1MAP3K12 | |
| SCHEMBL3829681 | 0.73 | CDK2 (0.36) | CDK2CDK1CCNB1MAP3K12CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183268-B2 | 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents | WAYNE STATE UNIVERSITY (US) | 2007-02-27 | — | — | US | disclosed |