Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.56 |
| ▸ | HTR2C | P28335 | 7/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5645754 | 0.89 | MCHR1 (0.68) | MCHR1HTR2CCLK2DYRK1ANPC1 | |
| SCHEMBL5645535 | 0.79 | KDM4E (0.56) | MCHR1HTR2CNPC1RAB9AMAPT | |
| SCHEMBL2925645 | 0.78 | MCHR1 (0.55) | MCHR1HTR2CWNT1CLK2CLK3 | |
| SCHEMBL5646747 | 0.75 | MCHR1 (0.73) | MCHR1HTR2CCLK2DYRK1ANPC1 | |
| SCHEMBL2929377 | 0.75 | MCHR1 (0.60) | MCHR1HTR2CABL1NPC1RAB9A | |
| SCHEMBL5645508 | 0.74 | MCHR1 (0.71) | MCHR1HTR2CMAPT | |
| SCHEMBL5644842 | 0.73 | MCHR1 (0.70) | MCHR1HTR2CABL1HDAC3HDAC1 | |
| SCHEMBL14619979 | 0.72 | MCHR1 (0.43) | MCHR1HTR2CNPC1MAPTHDAC1 | |
| SCHEMBL5648842 | 0.72 | MCHR1 (1.00) | MCHR1HTR2C | |
| SCHEMBL5646024 | 0.72 | MCHR1 (1.00) | MCHR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183415-B2 | Quinoline compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-27 | — | — | US | disclosed |