Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858651 | 0.85 | RAB9A (0.43) | FGFR4APPPAK1MAPK14NPC1 | |
| SCHEMBL858634 | 0.85 | ABL1 (0.42) | FGFR4APPPAK1GRM4NPC1 | |
| SCHEMBL859336 | 0.82 | JAK2 (0.43) | FGFR4APPPAK1MAPK14ALDH1A1 | |
| SCHEMBL858693 | 0.77 | FGFR4 (0.49) | FGFR4NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL859155 | 0.75 | MEN1 (0.45) | MAPTSMN1; SMN2 | |
| SCHEMBL859378 | 0.75 | FGFR4 (0.47) | FGFR4PAK1CYP2C9MAPK14SMN1; SMN2 | |
| SCHEMBL858194 | 0.73 | FGFR4 (0.48) | FGFR4NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL8002952 | 0.67 | AXL (0.51) | PAK1CYP2C9NPC1RAB9A | |
| SCHEMBL7995790 | 0.67 | PAK1 (0.47) | PAK1CYP2C9GRM4 | |
| SCHEMBL857351 | 0.66 | MAP2K1 (0.57) | PAK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002433-A1 | PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |