Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2739953 | 0.82 | PDCD1 (0.51) | PDCD1CD274ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2740275 | 0.80 | PDCD1 (0.51) | PDCD1CD274ALDH1A1HTTLMNA | |
| SCHEMBL2624512 | 0.78 | PDCD1 (0.51) | PDCD1CD274ALDH1A1LMNAMAPT | |
| SCHEMBL2740342 | 0.77 | SIRT1 (0.71) | PDCD1CD274ALDH1A1HTTLMNA | |
| SCHEMBL2740281 | 0.76 | KDM4E (0.51) | PDCD1CD274ALDH1A1HTTLMNA | |
| SCHEMBL2739954 | 0.74 | MEN1 (0.56) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2740115 | 0.73 | ABCG2 (0.55) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL4263319 | 0.73 | CYP2D6 (0.52) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL2740289 | 0.73 | SIRT1 (0.54) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13470801 | 0.72 | MEN1 (0.53) | PDCD1CD274ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043050-A1 | Sirtuin modulating compounds | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043050-A1 | Sirtuin modulating compounds | SIRT1, SIRT3, SIRT2 | PDCD1 3838/4885CD274 4509/4885ALDH1A1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.