Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 3/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786659 | 0.87 | TSHR (0.53) | TSHRCDC25BALDH1A1HSD17B10CLEC4M | |
| SCHEMBL12786651 | 0.84 | TSHR (0.50) | TSHRCDC25BALDH1A1HSD17B10CLEC4M | |
| SCHEMBL667108 | 0.84 | KDM4E (0.49) | TSHRALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL3638135 | 0.83 | MEN1 (0.49) | TSHRCDC25BALDH1A1HSD17B10KDM4E | |
| SCHEMBL7690740 | 0.80 | CDC25B (0.53) | TSHRCDC25BCCR6ALDH1A1HSD17B10 | |
| SCHEMBL27167364 | 0.79 | TSHR (0.50) | TSHRCDC25BCCR6ALDH1A1HSD17B10 | |
| SCHEMBL1462120 | 0.78 | CDC7 (0.42) | TSHRCCR6ALDH1A1KDM4EMAPK1 | |
| SCHEMBL10465592 | 0.77 | KMT2A (0.54) | TSHRALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL667822 | 0.77 | KDM4E (0.47) | ALDH1A1KDM4EKMT2AMEN1RAB9A | |
| SCHEMBL16112265 | 0.76 | TSHR (0.50) | TSHRCDC25BALDH1A1HSD17B10CLEC4M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | disclosed |
| EP-2493865-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011025938-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |
| US-20110053932-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2011-03-03 | — | — | US | disclosed |
| US-20110053932-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2011-03-03 | — | — | US | disclosed |
| US-20110053932-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2011-03-03 | — | — | US | disclosed |
| EP-2170842-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM, LLC (BM) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157575-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053932-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | BMX, FRK, FYN | TSHR 3326/4885CDC25B 553/4885CCR6 1997/4885 |
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | TSHR 2668/4885CDC25B 436/4885CCR6 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.