Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 5/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | STAT1 | P42224 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | MITF | O75030 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | JAK2 | O60674 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1463376 | 0.86 | RAB9A (0.76) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL24151517 | 0.85 | JAK3 (0.74) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL30191150 | 0.85 | JAK3 (0.74) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL15397453 | 0.84 | JAK3 (0.73) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL16176755 | 0.84 | JAK3 (0.73) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL1464227 | 0.84 | JAK3 (0.73) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL24150637 | 0.84 | JAK3 (0.72) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL30190706 | 0.84 | JAK3 (0.72) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL18886118 | 0.82 | JAK3 (0.70) | JAK3RAB9ANPC1TP53STAT1 | |
| SCHEMBL18886117 | 0.82 | JAK3 (0.69) | JAK3RAB9ANPC1TP53STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592415-B2 | Selective kinase inhibitors | REACTION BIOLOGY CORP. (US) | 2013-11-26 | — | — | US | claimed |
| EP-2396004-A1 | SELECTIVE KINASE INHIBITORS | Reaction Biology Corp. (US) | 2011-12-21 | — | — | EP | claimed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | claimed |
| WO-2010093808-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2010-08-19 | — | — | WO | claimed |
| US-8592415-B2 | Selective kinase inhibitors | REACTION BIOLOGY CORP. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2396004-A1 | SELECTIVE KINASE INHIBITORS | Reaction Biology Corp. (US) | 2011-12-21 | — | — | EP | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| WO-2010093808-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | JAK3, JAK1, JAK2 | JAK3 1/4885RAB9A 1139/4885NPC1 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.