Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473146 | 0.94 | RXRA (0.51) | RXRANR1H2NR1H3GRM1TRPM8 | |
| SCHEMBL3471474 | 0.87 | RXRA (0.52) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473564 | 0.78 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2SLC16A3 | |
| SCHEMBL3473562 | 0.78 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2SLC16A3 | |
| SCHEMBL3472163 | 0.77 | RXRA (0.60) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473683 | 0.77 | RXRA (0.49) | RXRANR1H2NR1H3NR3C2GPBAR1 | |
| SCHEMBL3472639 | 0.76 | RXRA (0.54) | RXRANR1H2NR1H3NR3C2GPBAR1 | |
| SCHEMBL3471729 | 0.76 | RXRA (0.60) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3471066 | 0.75 | RXRA (0.47) | RXRANR1H2NR1H3NR3C2IDH1 | |
| SCHEMBL14624835 | 0.75 | RXRA (0.51) | RXRANR1H2NR1H3NR3C2SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |