Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588059 | 0.88 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL1588442 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL17029109 | 0.86 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL12529773 | 0.84 | RAB9A (0.54) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL12529399 | 0.83 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL1587424 | 0.79 | HDAC6 (0.55) | NPC1RAB9ASMN1; SMN2AKT3CYP1A2 | |
| SCHEMBL1587804 | 0.78 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2AKT3CYP2C9 | |
| SCHEMBL12789016 | 0.78 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 | |
| SCHEMBL12723016 | 0.76 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2AKT3HDAC6 | |
| SCHEMBL11984349 | 0.75 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2USP2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010954-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2007-01-25 | — | — | WO | disclosed |