Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CCR1 | P32246 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.50 |
| ▸ | ME1 | P48163 | 1/20 | 0.50 |
| ▸ | ME3 | Q16798 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14626008 | 0.88 | CCR1 (0.59) | TP53CCR1MAPTSMN1; SMN2POLB | |
| SCHEMBL14626005 | 0.82 | TP53 (0.56) | TP53CCR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2874783 | 0.81 | CCR1 (0.58) | TP53CCR1MAPTPOLBALDH1A1 | |
| SCHEMBL13682907 | 0.81 | CCR1 (0.64) | TP53CCR1MAPTSMN1; SMN2POLB | |
| SCHEMBL13024653 | 0.81 | KMT2A (0.58) | TP53CCR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL2872952 | 0.80 | CCR1 (0.74) | TP53CCR1 | |
| SCHEMBL2874558 | 0.80 | CCR1 (0.61) | TP53CCR1MAPTSMN1; SMN2POLB | |
| SCHEMBL13066139 | 0.78 | CCR1 (0.59) | TP53CCR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL13024651 | 0.78 | MAPT (0.58) | TP53CCR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL13024644 | 0.78 | MAPT (0.58) | TP53CCR1MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157464-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2007-01-02 | — | — | US | disclosed |