Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CCR1 | P32246 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | VDR | P11473 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14625725 | 0.89 | CCR1 (0.55) | TP53MAPTALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL14625830 | 0.82 | TP53 (0.60) | TP53MAPTALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL2876617 | 0.82 | MAPT (0.55) | TP53MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL1384716 | 0.81 | MAPT (0.78) | TP53MAPTALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL2868491 | 0.78 | KMT2A (0.57) | TP53MAPTALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL2872007 | 0.75 | CCR1 (0.63) | MAPTALDH1A1CCR1KMT2AMEN1 | |
| SCHEMBL2870322 | 0.73 | CCR1 (0.64) | TP53MAPTALDH1A1CCR1POLB | |
| SCHEMBL13682907 | 0.73 | CCR1 (0.64) | TP53MAPTALDH1A1CCR1SMN1; SMN2 | |
| SCHEMBL2873980 | 0.73 | CCR1 (0.64) | TP53MAPTALDH1A1CCR1POLB | |
| SCHEMBL14039628 | 0.73 | CCR1 (0.64) | TP53MAPTALDH1A1CCR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157464-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2007-01-02 | — | — | US | disclosed |