Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25754564 | 0.86 | SIGMAR1 (0.54) | POLBHTTMAPTALDH1A1KDM4E | |
| SCHEMBL12359204 | 0.83 | MAPT (0.45) | POLBHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5109896 | 0.82 | MAPT (0.62) | POLBHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12847850 | 0.81 | MAPT (0.60) | POLBHTTMAPTALDH1A1KDM4E | |
| SCHEMBL8165558 | 0.81 | MAPT (0.66) | POLBMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12359038 | 0.80 | SMN1; SMN2 (0.47) | POLBMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14033271 | 0.80 | POLB (0.53) | POLBHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL17777943 | 0.79 | MAPT (0.57) | POLBHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29300046 | 0.78 | — | — | |
| SCHEMBL18538879 | 0.78 | MAPT (0.50) | POLBHTTMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000240-A1 | ISOQUINOLINE DERIVATIVES AS INHIBITORS OF RHO-KINASE | SANOFI-AVENTIS (DE) | 2007-01-04 | — | — | WO | disclosed |