Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.82 |
| ▸ | DRD3 | P35462 | 7/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204332 | 0.90 | HTR6 (0.82) | HTR6DRD3MEN1KMT2ADRD2 | |
| SCHEMBL14591390 | 0.84 | HTR6 (0.60) | HTR6DRD3DRD2 | |
| Trifluoroacetic Acid SCHEMBL5205906 | 0.82 | HTR6 (0.69) | HTR6DRD3MEN1KMT2ADRD2 | |
| SCHEMBL14591386 | 0.81 | HTR6 (0.58) | HTR6DRD3DRD2 | |
| Tert-Butyl Formate SCHEMBL27641071 | 0.80 | HTR6 (0.66) | HTR6DRD3MEN1KMT2ADRD2 | |
| SCHEMBL5200670 | 0.80 | HTR6 (0.66) | HTR6DRD3MEN1KMT2ADRD2 | |
| SCHEMBL5202880 | 0.78 | HTR6 (0.67) | HTR6DRD3MEN1KMT2AAKR1C3 | |
| SCHEMBL5201593 | 0.78 | HTR6 (0.64) | HTR6DRD3MEN1KMT2AAKR1C3 | |
| SCHEMBL5201623 | 0.78 | HTR6 (0.64) | HTR6DRD3MEN1KMT2ADRD2 | |
| SCHEMBL5204254 | 0.78 | HTR6 (0.62) | HTR6DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157463-B2 | Substituted piperidines/piperazines as melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-01-02 | — | — | US | disclosed |