Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 5/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.36 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14627484 | 0.89 | KDR (0.45) | RAF1BRAFKDRS1PR1CSNK1A1 | |
| SCHEMBL5464256 | 0.86 | RIPK1 (0.43) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL4170603 | 0.83 | KDR (0.52) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5447563 | 0.81 | TTBK1 (0.44) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5449703 | 0.79 | RIPK1 (0.42) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5451994 | 0.79 | RIPK1 (0.42) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5457064 | 0.79 | TTBK1 (0.44) | RIPK1RAF1BRAFKDRS1PR1 | |
| SCHEMBL4167598 | 0.79 | CDK1 (0.46) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5447951 | 0.78 | RAF1 (0.43) | RIPK1RAF1BRAFKDRCSNK1A1 | |
| SCHEMBL5459650 | 0.78 | RAF1 (0.43) | RIPK1RAF1BRAFKDRCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | MERCK PATENT GMBH (DE) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021456-A1 | Aminobenzimidazole derivatives | TIE1, KDR, FLT1 | RIPK1 1867/4885RAF1 17/4885BRAF 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.