Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ticarcillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | SLC6A1 | P30531 | 8/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ticarcillin SCHEMBL4935403 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4EHSD17B10 | |
| Ticarcillin SCHEMBL41224 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4EHSD17B10 | |
| Ticarcillin SCHEMBL41223 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2PTGS1LMNAKDM4EHSD17B10 | |
| Ticarcillin SCHEMBL18048101 | 0.75 | SMN1; SMN2 (0.88) | SMN1; SMN2PTGS1LMNAKDM4EHSD17B10 | |
| Tiagabine SCHEMBL5164417 | 0.73 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4ALMNAALDH1A1 | |
| Tiagabine SCHEMBL18496408 | 0.73 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4ALMNAALDH1A1 | |
| Ticarcillin SCHEMBL11113899 | 0.73 | SMN1; SMN2 (0.87) | SMN1; SMN2PTGS1LMNAKDM4EHSD17B10 | |
| Tiagabine SCHEMBL1527642 | 0.73 | SLC6A1 (0.98) | SLC6A1PTGS1PDE4ALMNAALDH1A1 | |
| Tiagabine SCHEMBL34653 | 0.73 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4ALMNAHSD17B10 | |
| Tiagabine SCHEMBL3272861 | 0.73 | SLC6A1 (1.00) | SLC6A1PTGS1PDE4ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494075-A2 | TEMPLATED NANOCONJUGATES | Northwestern University (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2473160-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | Northwestern University (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011053940-A2 | TEMPLATED NANOCONJUGATES | NORTHWESTERN UNIVERSITY (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011028850-A1 | DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS | NORTHWESTERN UNIVERSITY (US) | 2011-03-10 | — | — | WO | disclosed |