Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.83 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.83 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242311 | 0.91 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL1403549 | 0.84 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL1403545 | 0.84 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL5020703 | 0.82 | HDAC1 (0.74) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL8248523 | 0.82 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL5049507 | 0.80 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL5020627 | 0.80 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL5622158 | 0.80 | HDAC1 (0.80) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL8249933 | 0.80 | HDAC1 (0.80) | HDAC1HDAC4HDAC8HDAC3HDAC6 | |
| SCHEMBL1403430 | 0.80 | HDAC1 (1.00) | HDAC1HDAC4HDAC8HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748046-A2 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2007-01-31 | — | — | EP | disclosed |