Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326064 | 0.89 | PARP1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21751143 | 0.89 | PARP1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19389930 | 0.88 | PARP1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8726172 | 0.85 | RAB9A (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1660359 | 0.85 | ELANE (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL754805 | 0.84 | HTR2C (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1170552 | 0.84 | HTR2C (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31329634 | 0.84 | HTR2C (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2088860 | 0.84 | ABCB1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15352939 | 0.84 | ABCB1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548877-A1 | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors | MSD Oss B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |