Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14632076 | 0.86 | MAP2K1 (0.60) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14632094 | 0.86 | MAP2K1 (0.60) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14632038 | 0.85 | MAP2K1 (0.46) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL220539 | 0.85 | MAP2K1 (0.58) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL220540 | 0.85 | MAP2K1 (0.58) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14631997 | 0.84 | MAP2K1 (0.48) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14632037 | 0.83 | MAP2K1 (0.50) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14632019 | 0.83 | MAP2K1 (0.50) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14632073 | 0.81 | MAP2K1 (0.51) | MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL14631982 | 0.80 | MAP2K1 (0.52) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091941-B1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-01-23 | — | — | EP | claimed |