Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.41 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.41 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14632094 | 0.90 | MAP2K1 (0.60) | MAP2K1MAP2K2MAP2K5EIF2AK1BRAF | |
| SCHEMBL14632037 | 0.90 | MAP2K1 (0.50) | MAP2K1MAP2K2MAP2K5BRAFMAPK1 | |
| SCHEMBL14632019 | 0.90 | MAP2K1 (0.50) | MAP2K1MAP2K2MAP2K5BRAFMAPK1 | |
| SCHEMBL14632076 | 0.90 | MAP2K1 (0.60) | MAP2K1MAP2K2MAP2K5EIF2AK1BRAF | |
| SCHEMBL14632059 | 0.88 | MAP2K1 (0.53) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL220013 | 0.85 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1BRAF | |
| SCHEMBL220014 | 0.85 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1BRAF | |
| SCHEMBL14632038 | 0.84 | MAP2K1 (0.46) | MAP2K1MAP2K2MAP2K5BRAFMAPK1 | |
| SCHEMBL14631995 | 0.84 | MAP2K1 (0.46) | MAP2K1MAP2K2MAP2K5BRAFMAPK1 | |
| SCHEMBL14631982 | 0.83 | MAP2K1 (0.52) | MAP2K1MAP2K2MAP2K5EIF2AK1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091941-B1 | MAPK/ERK KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2013-01-23 | — | — | EP | claimed |