Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.77 |
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | JAK3 | P52333 | 11/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | MITF | O75030 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | STAT1 | P42224 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | JAK2 | O60674 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462316 | 0.87 | RAB9A (1.00) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1463310 | 0.85 | JAK3 (0.80) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1463421 | 0.84 | JAK3 (1.00) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1463316 | 0.84 | JAK3 (1.00) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL3711579 | 0.84 | JAK3 (0.78) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1462418 | 0.84 | RAB9A (0.77) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL12746063 | 0.83 | RAB9A (0.79) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1463291 | 0.82 | JAK3 (0.82) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL1462379 | 0.82 | JAK3 (0.74) | RAB9ANPC1JAK3MAPTMITF | |
| SCHEMBL12746040 | 0.82 | JAK3 (0.73) | RAB9ANPC1JAK3MAPTMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396004-A1 | SELECTIVE KINASE INHIBITORS | Reaction Biology Corp. (US) | 2011-12-21 | — | — | EP | claimed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | claimed |
| WO-2010093808-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2010-08-19 | — | — | WO | claimed |
| US-8592415-B2 | Selective kinase inhibitors | REACTION BIOLOGY CORP. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2396004-A1 | SELECTIVE KINASE INHIBITORS | Reaction Biology Corp. (US) | 2011-12-21 | — | — | EP | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2011-03-24 | — | — | US | disclosed |
| WO-2010093808-A1 | SELECTIVE KINASE INHIBITORS | REACTION BIOLOGY CORP. (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071149-A1 | SELECTIVE KINASE INHIBITORS | JAK3, JAK1, JAK2 | RAB9A 1139/4885NPC1 3267/4885JAK3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.