Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 10/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634052 | 0.84 | ABCB11 (0.54) | ABCB11EPHB4PAK1KDRCYP3A4 | |
| SCHEMBL14633693 | 0.81 | EPHB4 (0.48) | ABCB11EPHB4PAK1KDRCYP3A4 | |
| SCHEMBL14633924 | 0.80 | ABCB11 (0.41) | ABCB11EPHB4PAK1KDRCYP3A4 | |
| SCHEMBL2432312 | 0.79 | KDR (0.54) | ABCB11EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL14633736 | 0.79 | EPHB4 (0.61) | EPHB4KDRCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL2436346 | 0.79 | EPHB4 (0.46) | ABCB11EPHB4PAK1KDRCYP3A4 | |
| SCHEMBL14633921 | 0.78 | SYK (0.35) | METFLT3SYK | |
| SCHEMBL2435839 | 0.77 | KDR (0.46) | ABCB11EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL2464853 | 0.75 | EED (0.30) | — | |
| SCHEMBL14634207 | 0.75 | RIPK2 (0.46) | EPHB4KDRGAKRIPK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | ABCB11 3476/4885EPHB4 2462/4885PAK1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.