Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.33 |
| ▸ | AKT1 | P31749 | 6/20 | 0.33 |
| ▸ | MTOR | P42345 | 5/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14634162 | 0.78 | PLK4 (0.31) | PIK3CA | |
| SCHEMBL14633949 | 0.77 | EPHB4 (0.47) | — | |
| SCHEMBL14634102 | 0.67 | MAPK14 (0.32) | — | |
| SCHEMBL14633556 | 0.65 | NTRK1 (0.35) | PIK3CA | |
| SCHEMBL14634220 | 0.64 | ALOX5AP (0.33) | PIK3CA | |
| SCHEMBL2435150 | 0.64 | PIK3CA (0.51) | PIK3CAAKT1MTOR | |
| SCHEMBL14633973 | 0.61 | PAK1 (0.47) | — | |
| SCHEMBL14634007 | 0.60 | PIK3CA (0.39) | PIK3CA | |
| SCHEMBL24198359 | 0.58 | CHEK1 (0.41) | — | |
| SCHEMBL14634163 | 0.58 | RIPK2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | claimed |
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023532-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | MAP3K19, MAP3K1, MAP3K20 | PIK3CA 78/4885AKT1 83/4885MTOR 172/4885 |
| US-20130023534-A1 | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | CDK2, MAP3K19, MAP3K1 | PIK3CA 99/4885AKT1 80/4885MTOR 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.